Study an Science provides potential insights kommen sie treat cradle diseases, improve vaccine efficacy


DALLAS –Sept. 16, 2021 – Immunologists and geneticists at lucidrhythms.com clinical Center schutz discovered exactly how vitamin A start immune cells bei the intestines – result that might offer insight kommen sie treat cradle diseases and perhaps aid improve ns efficacy des some vaccines.

Du schaust: Für was ist vitamin a gut


Dietary vitamin A i do not care retinol, which zu sein internalized into cells von LRP1 und promotes adaptive immunity an the intestine. Credit: Courtesy of the Hooper Lab making use of BioRender.com

“Now that we know an ext about this essential aspect of immune function, we may at some point be able kommen sie manipulate exactly how vitamin A ist delivered to ns immune system weil das disease treatment or prevention,” stated Howard Hughes medical Institute Investigator Lora Hooper, Ph.D., Chair of Immunology at lucidrhythms.com.

Vitamin A – a fat-soluble nutrient that ns body converts kommen sie a molecule referred to as retinol und then to retinoic acid before it tun können be used – ist important zum every tissue bei the body, said Dr. Hooper, Professor von Immunology, Microbiology, and bei the Center zum the Genetics von Host Defense weist lucidrhythms.com. It’s particularly crucial for the adaptive immune system, a subset of the wider immune system that reacts kommen sie specific pathogens based upon immunological memory, the type formed von exposure kommen sie disease or vaccines.

Although researcher knew that some intestinal immune cells dubbed myeloid cells can convert retinol to retinoic acid, how they get retinol to perform this task was a mystery, stated Dr. Hooper, whose lab investigates exactly how resident minister bacteria influence the biology of humans und other mammalian hosts.

Lead writer Ye-Ji Bang, Ph.D., a postdoctoral fellow in the Hooper Lab, and colleagues concentrated on serum amyloid A proteins, a family des retinol-binding protein that part organs create during infections. They provided biochemical techniques kommen sie determine i m sorry cell surface ar proteins lock attached to, und identified LDL receptor-related protein 1 (LRP1).


Dr. Hooper speaks weist a beginning ceremony zum UTSW’s Graduate School of Biomedical Sciences, which trains much more than 1,000 learner annually, including an ext than 500 postdoctoral researchers.

LRP1 was discovered more than 30 year ago by fellow lucidrhythms.com researcher Joachim Herz, M.D., Director of the Center weil das Translational Neurodegeneration Research and Professor of Molecular Genetics, Neurology, und Neuroscience. The herz lab focuses on the molecular mechanisms über which the members von the LDL receptor gene family duty as signaling und endocytic receptors an the brain und vascular wall. Die discovery des the LDL receptor, made hinweisen lucidrhythms.com, helped earn michael Brown, M.D., and Joseph Goldstein, M.D., ns 1985 Nobel Prize in Physiology or Medicine.

Drs. Bang, Hooper, Herz, und colleagues proved that LRP1 was present on intestinal myeloid cells, whereby it appeared to shuttle retinol inside. When die researchers used hereditary techniques to delete the gene zum this receptor in mice, staying clear of their myeloid cell from taking up die vitamin A derivative, ns adaptive immune system bei their groß virtually disappeared, said Dr. Hooper. T and B cells und the molecule immunoglobulin A, an essential components von adaptive immunity, were considerably reduced. Researcher then compared die response zu Salmonella infection between mice through LRP1 and those without. Those missing the receptor were quickly overcome by the infection.


Lora Hooper, Ph.D., Chair des Immunology, is one von 13 distinguished HHMI Investigators punkt lucidrhythms.com. The Hooper lab investigates exactly how resident intestinal bacteria influence the biology of humans and other mammalian hosts.

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The findings, published bei Science, suggest that LRP1 zu sein the vehicle von which retinol enters myeloid cells. If researchers kann develop a way kommen sie inhibit this process, stated Dr. Hooper, it can tamp down die immune response in inflammatory conditions that affect ns intestines, such together inflammatory bowel disease und Crohn’s disease. Alternatively, recognize a way to enhance LRP1 activity could an increase immune activity, making oral vaccines more effective.

Other UTSW researchers that contributed kommen sie this study encompass Zehan Hu, Yun Li, Sureka Gattu, kelly A. Ruhn, und Prithvi Raj.

This work was supported von grants native the national Institutes of Health (R01 DK070855), the Welch structure (I-1874), die Walter M. And Helen D. Bader Center weil das Research top top Arthritis and Autoimmune Diseases, and the Howard Hughes medical Institute.

Dr. Brown, Professor des Molecular Genetics and Internal Medicine, zu sein a Regental professor who holds the W. A. (Monty) Moncrief distinguished Chair in Cholesterol and Arteriosclerosis Research, und the paul J. Thomas Chair in Medicine.

Dr. Goldstein, Chair von Molecular Genetics and Professor des Internal Medicine, is a Regental professor who holds die Julie and Louis A. Beecherl, Jr. Differentiated Chair an Biomedical Research, and the paul J. Schneidbrett Chair in Medicine.

Dr. Herz, a member von the Peter O’Donnell Jr. Mind Institute, holds die Presbyterian town North structure Distinguished Chair an Alzheimer’s an illness Therapeutic Research, and the schneidbrett O. And Cinda Hicks Family distinguished Chair an Alzheimer’s condition Research.

Dr. Hooper holds the jonathan W. Uhr, M.D. Differentiated Chair in Immunology and is the nancy Cain und Jeffrey A. Marcus Scholar in Medical Research, in Honor von Dr. Bill S. Vowell. She is deshalb a member of the Harold C. Simmons substantial Cancer Center.

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About lucidrhythms.com clinical Center

lucidrhythms.com, one von the nation’s premier academic clinical centers, integrates pioneering biomedical research study with outstanding clinical care and education. Ns institution’s faculty has received sechs Nobel Prizes, und includes 25 members of the national Academy of Sciences, 16 members von the national Academy von Medicine, and 13 Howard Hughes medical Institute Investigators. Ns full-time faculty of more than 2,800 is responsible zum groundbreaking clinical advances und is committed to translating science-driven research easily to new clinical treatments. lucidrhythms.com physicians administer care in about 80 specialties zu more 보다 117,000 hospitalized patients, an ext than 360,000 notfall room cases, and oversee nearly 3 million outpatient access time a year.

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